https://blog.ambrygen.com/list/category/Variant%20of%20Unknown%20Significance Find the latest Ambry Genetics news by category: Variant of Unknown Significance en https://blog.ambrygen.com/list/category/Variant%20of%20Unknown%20Significance https://blog.ambrygen.com/assets/img/logo/Ambry_logo_web.jpg https://blog.ambrygen.com/ambry/post/363/striking-the-perfect-balance-in-designing-hereditary-cancer-tests-the-ambry-approach Ambry's balanced approach to designing hereditary cancer tests ensures our panels remain relevant and impactful, helping clinicians manage hereditary cancer risk with confidence. Thu, 31 Oct 24 08:40:00 -0700 Ambry Genetics Ambry Blog Variant of Unknown Significance https://blog.ambrygen.com/ambry/post/362/the-evolution-of-hereditary-cancer-testing-why-pan-cancer-panels-are-the-future-of-genetic-risk-assessment Pan-cancer panels offer more comprehensive diagnoses, personalized risk assessments, and targeted prevention and treatment strategies. Thu, 17 Oct 24 08:18:00 -0700 Ambry Genetics Ambry Blog Variant of Unknown Significance https://blog.ambrygen.com/ambry/post/344/apc-new-takes-on-an-old-gene Pathogenic variants in the APC gene cause conditions such as FAP and GAPPS. Marcy Richardson breaks down genotype-phenotype correlations and how they cause one condition or presentation versus another. Thu, 28 Mar 24 03:45:00 -0700 Ambry Genetics Ambry Blog Variant of Unknown Significance https://blog.ambrygen.com/ambry/post/338/greater-than-the-sum-of-its-parts-gene-disease-validity-and-breast-cancer Jennifer Herrera-Mullar discusses the correlation between breast-cancer associated genes and gene-disease validity Tue, 05 Mar 24 03:00:00 -0800 Ambry Genetics Ambry Blog Variant of Unknown Significance https://blog.ambrygen.com/ambry/post/337/variant-interpretation-in-real-time-sometimes-it-takes-a-village Genetic counselors explain how a CDH1 variant was classified as likely pathogenic from VUS status. Fri, 23 Feb 24 08:36:00 -0800 Ambry Genetics Ambry Blog Variant of Unknown Significance https://blog.ambrygen.com/ambry/post/328/the-path-to-clinical-relevance-what-a-study-on-rad51c-reveals-about-resolving-vus Marcy Richardson, PhD discusses variant interpretation, VUS, and recategorizing missense genes with an example from Hu et al's recent publication on RAD51C. Tue, 19 Dec 23 08:22:00 -0800 Ambry Genetics Ambry Blog Variant of Unknown Significance https://blog.ambrygen.com/patient/post/324/peace-of-mind-michelle-majewski-trusts-the-patient-for-life-program-to-share-answers-for-her-son-owen Michelle Majewski juggles a career as a sales account executive, husband, and son Owen, who has extra medical needs, without a clear diagnosis. The search for answers used to keep Michelle up at night, before ExomeNext. Tue, 14 Nov 23 06:27:00 -0800 Ambry Genetics Patient Blog Variant of Unknown Significance https://blog.ambrygen.com/ambry/post/319/genetics-in-medicine-publication-demonstrates-a-10-lower-rate-of-vus-with-wes-wgs-compared-to-panels A discussion of VUS and explanation of their significance, highlighting Ambry's collaboration in the GIM publication, The landscape of reported VUS in multi-gene panel and genomic testing: Time for a change. Wed, 20 Sep 23 04:18:00 -0700 Ambry Genetics Ambry Blog Variant of Unknown Significance https://blog.ambrygen.com/ambry/post/265/5-things-you-need-to-know-about-ambry-s-variant-review-process Genetic testing laboratories should have a defined process to regularly review the evidence for genetic variants, so they can eventually come to a verdict and provide a more clear answer. Thu, 23 Aug 18 12:45:00 -0700 Ambry Genetics Ambry Blog Variant of Unknown Significance https://blog.ambrygen.com/ambry/post/172/dr-rachid-karam-discusses-variant-classification-at-2017-acmg-annual-meeting During the 2017 ACMG Annual Meeting, Rachid Karam, MD, PhD, discussed how understanding VUS results can help clinicians create medical management plans for their patients. Thu, 30 Mar 17 19:06:00 -0700 Ambry Genetics Ambry Blog Variant of Unknown Significance https://blog.ambrygen.com/ambry/post/163/rna-labs-how-they-impact-the-medical-world By having the ATG Lab at Ambry, it is possible to further refine VUS results and look beyond DNA in order to determine the benign or pathogenic status of splicing. Thu, 02 Mar 17 23:46:00 -0800 Ambry Genetics Ambry Blog Variant of Unknown Significance