• By Huma Q. Rana, MD, MPH
• Posted December 30, 2025

Study Finds One in Four People With Sarcoma Carry a Pathogenic Variant: Why Germline Testing Matters

I am excited to share results of our large case-control study of 488 people with sarcoma and 2,440 matched cancer-free controls. Our study published in the Journal of the National Cancer Institute (JNCI) sought to determine whether germline pathogenic variants (gPVs) were more frequent in people with sarcoma than in cancer-free controls…