• By Noelle Carbognin
  • Posted March 22, 2024

Transforming Fear into Action and Advocacy: Our Family’s Lynch Syndrome Story

It has been almost 3 years since my father was offered genetic testing after developing three different types of cancers. He also had an alarming family history – multiple relatives with cancer, going back generations. After he received a positive result for Lynch Syndrome, putting him at an increased risk for colon cancer and other types of…


  • By Jodi Tahsler
  • Posted April 11, 2023

Meet the Gene Team: Jeni Herrera-Mullar, MGC, CGC, DMA, presents the Gene of the Month, MSH3

Meet the Gene Team The Gene Team is an essential part of Ambry Genetics. This passionate team of experts is inspired by advancing the science of gene characterization and being able to help patients. For our second installment, we would like to introduce Jeni Herrera-Mullar, MGC, CGC, DMA, Principal Clinical Scientist at Ambry Genetics. Jeni…


  • By Catherine Schultz, MS, CGC
  • Posted March 23, 2023

Ambry Genetics Diagnostic Dilemma: +RNAinsight® Reveals Lynch Syndrome in Sisters

In recognition of Colon Cancer Awareness Month, Ambry would like to share the story of Jane and Julie Smith (not their real names) – sisters and cancer survivors. Jane was diagnosed with colon cancer in 2004 at the age of 36. While she was concerned about her diagnosis and family history of ovarian cancer, genetic testing was not widely available…


  • By Noelle Carbognin
  • Posted February 17, 2022

Thanks to Genetic Testing, I Now Know My Cancer Risk

“It’s one thing to be scared to hear something, it’s another to die from not hearing something at all.”Rick, Colon & Kidney Cancer Survivor (American Cancer Society) When I was twelve years old, my cousin was diagnosed with Stage 4 colon cancer. She was only 24. My mother knew my grandfather on…


  • By Monalyn Umali Salvador, MS, CGC
  • Posted April 4, 2019

Paired Tumor/Germline Testing for Lynch Syndrome

When I think back to the initial discussions about what is now TumorNext-Lynch, I remember a vision to offer a comprehensive and convenient test that would be able to confirm a diagnosis or indicate a significantly reduced likelihood of Lynch syndrome. It was clear that the best approach to achieve this was to develop a paired tumor/germline…


  • By Jessica Profato, MS, CGC
  • Posted October 16, 2017

Identifying Patients with Lynch Syndrome: A Paired Somatic/Germline Testing Approach

Lynch syndrome is one of the most common hereditary cancer syndromes, affecting about 1/279-1/440 people in the U.S. It is caused by a genetic mutation in one of five genes: MLH1, MSH2, MSH6, PMS2, or EPCAM. Individuals with Lynch syndrome have a significantly increased lifetime risk for multiple types of cancer including colorectal…


  • By Jessica Profato, MS, CGC
  • Posted September 25, 2017

Knowledge is Power: Learn More About Lynch Syndrome

Over the past few years, hereditary breast and ovarian cancer, and the BRCA1 and BRCA2 genes, have received a lot of media attention. From the perspective of a Genetic Counselor, I can say that these stories have helped raise awareness about hereditary cancer and the importance of understanding your family history. I hope that…


  • By Deepti Babu, MS, CGC
  • Posted May 17, 2017

Lynch Syndrome - It's more common than you think

Did you know that more than 1 in 4 of those with Lynch syndrome (LS) are missed by current genetic testing guidelines? New research from Ambry Genetics and Ohio State University of nearly 35,000 patients will change how the genetics community thinks about genetic testing strategies, lifetime cancer risks, and medical management for people with…